In 1961 Antonio Margheriti tried to make a film out of the catastrophic tragedy happened in Sicily at the beginning of the century, with "The Messina's Earthquake", a project he had together with Turi Vasile, and for which he shoot a promo trailer of special effects, combining the collapsing of the miniatures and shots with the actors. But Titanus decide not to make the film, so Antonio gets his revenge whit this Peplum "The Fault of Rome" and he destroy with an Earthquake the eternal city of Rome.

The first Antonio's film produced by his good friend Marco Vicario, owner of the Atlantica Cinematografica, who will make with this same company, other two films with Antonio: "The Virgin of Nuremberg" ("Horror Castle" US Title) a masterpiece of the Italian Gothic-Horror production and "Weird, Wicked World" a sort of a shocking Documentary that Marco Vicario co-direct with the pseudo of Renato Marvi.

In "The Fault of Rome", as usual, Antonio combine several genres, and in addition he made the first "Catastrophic" Italian movie. In fact, this is an Historical-Adventure film, with a lot of battles and action scenes, including the Gladiators fight in the Coliseum, but at the end the entire city become shaken and destroyed by a tremendous Earthquake, which will buried thousands of Romans including our hero. Antonio Margheriti direct this adventure story with a tragic end, where nobody wins against the fury of the elements who symbolically erase in this way the sins of the humanity.